Booster of mRNA-1273 Vaccine Reduces SARS-CoV-2 Omicron Escape from Neutralizing Antibodies.

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ID: 274870
2021
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Ranked #10 of 12 articles by views in medRxiv : the preprint server for health sciences

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Abstract
The Omicron variant of SARS-CoV-2 is raising concerns because of its increased transmissibility and potential for reduced susceptibility to antibody neutralization. To assess the potential risk of this variant to existing vaccines, serum samples from mRNA-1273 vaccine recipients were tested for neutralizing activity against Omicron and compared to neutralization titers against D614G and Beta in a pseudovirus assay in two different laboratories. Omicron was 49-84-fold less sensitive to neutralization than D614G and 5.3-6.2-fold less sensitive than Beta when assayed with serum samples obtained 4 weeks after 2 standard inoculations with 100 µg mRNA-1273. A 50 µg boost increased Omicron neutralization titers and may substantially reduce the risk of symptomatic vaccine breakthrough infections.
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doriarose2021boostermedrxiv Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Doria-Rose, Nicole A;Shen, Xiaoying;Schmidt, Stephen D;O'Dell, Sijy;McDanal, Charlene;Feng, Wenhong;Tong, Jin;Eaton, Amanda;Maglinao, Maha;Tang, Haili;Atmar, Robert L;Lyke, Kirsten E;Wang, Lingshu;Zhang, Yi;Gaudinski, Martin R;Black, Walker P;Gordon, Ingelise;Guech, Mercy;Ledgerwood, Julie E;Misasi, John N;Widge, Alicia;Roberts, Paul C;Beigel, John;Korber, Bette;Pajon, Rolando;Mascola, John R;Montefiori, David C;
Journal medRxiv : the preprint server for health sciences
Year 2021
DOI
2021.12.15.21267805
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