Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy

Clicks: 481
ID: 274665
1998
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Abstract
Overexpression of the nuclear form of sterol regulatory element-binding protein-1c (nSREBP-1c/ADD1) in cultured 3T3-L1 preadipocytes was shown previously to promote adipocyte differentiation. Here, we produced transgenic mice that overexpress nSREBP-1c in adipose tissue under the control of the adip …
Reference Key
i1998genesinsulin Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Shimomura I;Hammer RE;Richardson JA;Ikemoto S;Bashmakov Y;Goldstein JL;Brown MS;;
Journal genes & development
Year 1998
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/9784493
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice RNA animals pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't u.s. gov't female male Disease Models Animal Comparative Study P.H.S. phenotype Liver / pathology Adipose Tissue / metabolism* Blood Glucose / metabolism Messenger / biosynthesis diabetes mellitus insulin / blood dna-binding proteins / genetics cell differentiation / genetics insulin resistance / genetics* nuclear proteins / genetics transcription factors* sterol regulatory element binding protein 1 m s brown ccaat-enhancer-binding proteins* dna-binding proteins / biosynthesis* experimental / genetics* pmid:9784493 pmc317215 doi:10.1101/gad.12.20.3182 i shimomura r e hammer adipose tissue / pathology newborn / growth & development lipoatrophic / genetics* lipoatrophic / physiopathology transgenic* / genetics transgenic* / growth & development transgenic* / metabolism nuclear proteins / biosynthesis* transgenes

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