Conditional lethality of the diprotic weak bases chloroquine and quinacrine against Cryptococcus neoformans

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2000
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Abstract
Chloroquine at 10 microM enhances the activity of macrophages against Cryptococcus neoformans but does not directly inhibit cryptococcal growth. The antifungal activity of higher chloroquine concentrations likely to be found within the acidic cryptococcal phagosome was tested. Concentrations of > …
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Authors Harrison TS;Griffin GE;Levitz SM;;
Journal The Journal of infectious diseases
Year 2000
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/10882608
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't u.s. gov't P.H.S. microbial sensitivity tests drug combinations enzyme inhibitors / pharmacology anti-bacterial agents / pharmacology cell division / drug effects antifungal agents / pharmacology* chloroquine / pharmacology* t s harrison s m levitz macrolides* pmid:10882608 doi:10.1086/315649 g e griffin cryptococcus neoformans / drug effects* cryptococcus neoformans / metabolism quinacrine / pharmacology*

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