Anti-Inflammatory Therapies for Treatment of Inflammation-Related Preterm Brain Injury

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ID: 274609
2021
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Abstract
Despite the prevalence of preterm brain injury, there are no established neuroprotective strategies to prevent or alleviate mild-to-moderate inflammation-related brain injury. Perinatal infection and inflammation have been shown to trigger acute neuroinflammation, including proinflammatory cytokine release and gliosis, which are associated with acute and chronic disturbances in brain cell survival and maturation. These findings suggest the hypothesis that the inhibition of peripheral immune responses following infection or nonspecific inflammation may be a therapeutic strategy to reduce the associated brain injury and neurobehavioral deficits. This review provides an overview of the neonatal immunity, neuroinflammation, and mechanisms of inflammation-related brain injury in preterm infants and explores the safety and efficacy of anti-inflammatory agents as potentially neurotherapeutics.
Reference Key
prasad2021internationalanti-inflammatory Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Jaya D. Prasad;Katherine C. Gunn;Joanne O. Davidson;Robert Galinsky;Scott E. Graham;Mary J. Berry;Laura Bennet;Alistair J. Gunn;Justin M. Dean;Prasad, Jaya D.;Gunn, Katherine C.;Davidson, Joanne O.;Galinsky, Robert;Graham, Scott E.;Berry, Mary J.;Bennet, Laura;Gunn, Alistair J.;Dean, Justin M.;
Journal International journal of molecular sciences
Year 2021
DOI
10.3390/ijms22084008
URL
https://doi.org/10.3390/ijms22084008
Keywords
inflammation infection neuroprotection white matter injury

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