Ectopic expression of the nude gene induces hyperproliferation and defects in differentiation: implications for the self-renewal of cutaneous epithelia

Clicks: 263
ID: 274600
1999
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Abstract
Nude mice are characterized by the absence of visible hair, epidermal defects, and the failure to develop a thymus. This phenotype results from loss-of-function mutations in Whn (Hfh11), a winged-helix transcription factor. In murine epidermis and hair follicles, endogenous whn expression is induced …
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Authors Prowse DM;Lee D;Weiner L;Jiang N;Magro CM;Baden HP;Brissette JL;;
Journal Developmental biology
Year 1999
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/10419685
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice animals humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't u.s. gov't P.H.S. phenotype DNA-Binding Proteins / genetics* time factors transcription factors / genetics* cell differentiation dose-response relationship drug transgenic epithelium / metabolism cell culture techniques cell division skin transplantation DNA-Binding Proteins / immunology forkhead transcription factors calcium / pharmacology transcription factors / immunology pmid:10419685 doi:10.1006/dbio.1999.9328 d m prowse d lee j l brissette eye abnormalities / genetics keratinocytes nude / genetics* protein precursors / genetics skin / metabolism* skin abnormalities / genetics transforming growth factor alpha / metabolism urogenital system / anatomy & histology vibrissae / metabolism vibrissae / ultrastructure

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