A Serine-Substituted P450 Catalyzes Highly Efficient Carbene Transfer to Olefins In Vivo

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ID: 274509
2013
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Abstract
Genetically encoded catalysts for non-natural chemical reactions will open new routes to sustainable production of chemicals. We designed a unique serine-heme ligated cytochrome “P411” that catalyzes efficient and selective carbene transfers ...
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Authors Pedro S. Coelho, Z. Jane Wang, Maraia E. Ener, Stefanie A. Baril, Arvind A. Kannan, Frances H. Arnold, Eric M. Brustad;Pedro S. Coelho;Z. Jane Wang;Maraia E. Ener;Stefanie A. Baril;Arvind A. Kannan;Frances H. Arnold;Eric M. Brustad;
Journal Nature Chemical Biology
Year 2013
DOI
10.1038/nchembio.1278
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