Diet-induced obesity causes ghrelin resistance in arcuate NPY/AgRP neurons

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ID: 274239
2010
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Abstract
Circulating ghrelin is decreased in obesity, and peripheral ghrelin does not induce food intake in obese mice. We investigated whether ghrelin resistance was a centrally mediated phenomenon involving dysregulated neuropeptide Y (NPY) and agouti-related peptide (AgRP) circuits. We show that diet-indu …
Reference Key
di2010endocrinologydiet-induced Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Briggs DI;Enriori PJ;Lemus MB;Cowley MA;Andrews ZB;;
Journal endocrinology
Year 2010
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/20826561
Keywords
diet National Center for Biotechnology Information NCBI NLM MEDLINE Mice Inbred C57BL animals pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't male cognition / drug effects neurons / metabolism obesity / complications obesity / blood obesity / metabolism* eating / physiology eating / drug effects neuropeptide y / metabolism* obese goats growth hormone / metabolism zane b andrews agouti-related protein / metabolism* ghrelin / genetics ghrelin / metabolism* ghrelin / pharmacology pmid:20826561 doi:10.1210/en.2010-0556 dana i briggs pablo j enriori arcuate nucleus of hypothalamus / metabolism* cognition / physiology atherogenic drug resistance* / physiology ghrelin / blood obesity / etiology

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