Disposition of amodiaquine and related antimalarial agents in human neutrophils: implications for drug design

Clicks: 337
ID: 274238
1997
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Abstract
The development and clinical use of 4-aminoquinoline antimalarial agents such as amodiaquine have been limited by toxicity to neutrophils. We have investigated the chemical basis of amodiaquine-induced toxicity and compared the findings with those for established antimalarial drugs proposed for huma …
Reference Key
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Authors Naisbitt DJ;Ruscoe JE;Williams D;O'Neill PM;Pirmohamed M;Park BK;;
Journal the journal of pharmacology and experimental therapeutics
Year 1997
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/9023303
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't in vitro techniques leukocytes cell survival / drug effects molecular structure structure-activity relationship tetradecanoylphorbol acetate / pharmacology drug design tritium mononuclear / metabolism* neutrophils / pathology pmid:9023303 d j naisbitt j e ruscoe b k park amodiaquine / analogs & derivatives* amodiaquine / blood* amodiaquine / pharmacokinetics amodiaquine / toxicity antimalarials / blood* antimalarials / pharmacokinetics antimalarials / toxicity glutathione / blood mononuclear / drug effects mononuclear / pathology neutrophils / drug effects neutrophils / metabolism*

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