Autologous haematopoietic stem-cell transplantation versus bortezomib-melphalan-prednisone, with or without bortezomib-lenalidomide-dexamethasone consolidation therapy, and lenalidomide maintenance for newly diagnosed multiple myeloma (EMN02/HO95): a multicentre, randomised, open-label, phase 3 study

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ID: 274192
2020
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Abstract
Janssen and Celgene.
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Authors Cavo M;Gay F;Beksac M;Pantani L;Petrucci MT;Dimopoulos MA;Dozza L;van der Holt B;Zweegman S;Oliva S;van der Velden VHJ;Zamagni E;Palumbo GA;Patriarca F;Montefusco V;Galli M;Maisnar V;Gamberi B;Hansson M;Belotti A;Pour L;Ypma P;Grasso M;Croockewit A;Ballanti S;Offidani M;Vincelli ID;Zambello R;Liberati AM;Andersen NF;Broijl A;Troia R;Pascarella A;Benevolo G;Levin MD;Bos G;Ludwig H;Aquino S;Morelli AM;Wu KL;Boersma R;Hajek R;Durian M;von dem Borne PA;Caravita di Toritto T;Zander T;Driessen C;Specchia G;Waage A;Gimsing P;Mellqvist UH;van Marwijk Kooy M;Minnema M;Mandigers C;Cafro AM;Palmas A;Carvalho S;Spencer A;Boccadoro M;Sonneveld P;;
Journal The Lancet. Haematology
Year 2020
DOI
DOI not found
URL
https://www.pubmed.gov/32359506/
Keywords
transplantation injections Administration National Center for Biotechnology Information NCBI NLM MEDLINE humans pubmed abstract nih national institutes of health national library of medicine female male middle aged Comparative Study Clinical Trial Phase III Randomized Controlled Trial Multicenter Study neutropenia / chemically induced neoplasm staging dexamethasone / administration & dosage disease-free survival melphalan / administration & dosage prednisone / administration & dosage hematopoietic stem cell transplantation / adverse effects* hematopoietic stem cell transplantation / mortality autologous / mortality intravenous dexamethasone / therapeutic use prednisone / therapeutic use subcutaneous antineoplastic combined chemotherapy protocols / therapeutic use infections / epidemiology neutropenia / epidemiology Melphalan / therapeutic use multiple myeloma / drug therapy* francesca gay multiple myeloma / diagnosis pmid:32359506 doi:10.1016/s2352-3026(20)30099-5 michele cavo pieter sonneveld bortezomib / administration & dosage bortezomib / therapeutic use consolidation chemotherapy / methods* gastrointestinal diseases / chemically induced gastrointestinal diseases / epidemiology infections / chemically induced lenalidomide / administration & dosage lenalidomide / therapeutic use myeloma proteins / analysis plasmacytoma / pathology thrombocytopenia / chemically induced thrombocytopenia / epidemiology autologous / methods*

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