UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals

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ID: 274189
2008
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Abstract
The gut-derived hormone ghrelin exerts its effect on the brain by regulating neuronal activity. Ghrelin-induced feeding behaviour is controlled by arcuate nucleus neurons that co-express neuropeptide Y and agouti-related protein (NPY/AgRP neurons). However, the intracellular mechanisms triggered by …
Reference Key
zb2008natureucp2 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Andrews ZB, Liu ZW, Walllingford N, Erion DM, Borok E, Friedman JM, Tschöp MH, Shanabrough M, Cline G, Shulman GI, Coppola A, Gao XB, Horvath TL, Diano S
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Journal Nature
Year 2008
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/18668043
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice animals pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't N.I.H. Extramural Phosphorylation / drug effects gene expression regulation / drug effects reactive oxygen species / metabolism* neurons / drug effects fatty acids / metabolism mitochondria / drug effects neurons / metabolism* membrane potential mitochondrial / drug effects feeding behavior / drug effects synapses / metabolism hypothalamus / metabolism hypothalamus / drug effects neuropeptide y / metabolism* mitochondria / physiology zane b andrews agouti-related protein / genetics agouti-related protein / metabolism* ghrelin / metabolism* neuropeptide y / genetics pmid:18668043 pmc4101536 doi:10.1038/nature07181 zhong-wu liu sabrina diano carnitine o-palmitoyltransferase / metabolism ghrelin / pharmacology ion channels / genetics ion channels / metabolism* mitochondrial / physiology mitochondrial proteins / genetics mitochondrial proteins / metabolism* synapses / drug effects uncoupling protein 2

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