UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals

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ID: 274189
2008
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Abstract
The gut-derived hormone ghrelin exerts its effect on the brain by regulating neuronal activity. Ghrelin-induced feeding behaviour is controlled by arcuate nucleus neurons that co-express neuropeptide Y and agouti-related protein (NPY/AgRP neurons). However, the intracellular mechanisms triggered by …
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Authors Andrews ZB;Liu ZW;Walllingford N;Erion DM;Borok E;Friedman JM;Tschöp MH;Shanabrough M;Cline G;Shulman GI;Coppola A;Gao XB;Horvath TL;Diano S;;
Journal Nature
Year 2008
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/18668043
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice animals pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't N.I.H. Extramural Phosphorylation / drug effects gene expression regulation / drug effects reactive oxygen species / metabolism* neurons / drug effects fatty acids / metabolism mitochondria / drug effects neurons / metabolism* membrane potential mitochondrial / drug effects feeding behavior / drug effects synapses / metabolism hypothalamus / metabolism hypothalamus / drug effects neuropeptide y / metabolism* mitochondria / physiology zane b andrews agouti-related protein / genetics agouti-related protein / metabolism* ghrelin / metabolism* neuropeptide y / genetics pmid:18668043 pmc4101536 doi:10.1038/nature07181 zhong-wu liu sabrina diano carnitine o-palmitoyltransferase / metabolism ghrelin / pharmacology ion channels / genetics ion channels / metabolism* mitochondrial / physiology mitochondrial proteins / genetics mitochondrial proteins / metabolism* synapses / drug effects uncoupling protein 2

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