Polo kinase regulates mitotic chromosome condensation by hyperactivation of condensin DNA supercoiling activity

Clicks: 297
ID: 274163
2009
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Abstract
A defining feature of mitosis is the reorganization of chromosomes into highly condensed structures capable of withstanding separation and large-scale intracellular movements. This reorganization is promoted by condensin, an evolutionarily conserved multisubunit ATPase. Here we show, using budding y …
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Authors St-Pierre J;Douziech M;Bazile F;Pascariu M;Bonneil E;Sauvé V;Ratsima H;D'Amours D;;
Journal molecular cell
Year 2009
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/19481522
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't amino acid sequence DNA DNA-Binding Proteins / metabolism* Molecular Sequence Data sequence homology amino acid chromosomes dna-binding proteins / genetics phosphorylation cell cycle proteins / genetics cell cycle proteins / metabolism* saccharomyces cerevisiae / genetics adenosine triphosphatases / metabolism* protein-serine-threonine kinases / genetics saccharomyces cerevisiae / metabolism aurora kinases protein-serine-threonine kinases / metabolism protein kinases / genetics saccharomyces cerevisiae proteins / genetics saccharomyces cerevisiae proteins / metabolism* protein subunits / genetics protein subunits / metabolism cdc2 protein kinase / genetics adenosine triphosphatases / genetics pmid:19481522 doi:10.1016/j.molcel.2009.04.013 julie st-pierre mélanie douziech damien d'amours anaphase / physiology* cdc2 protein kinase / metabolism fungal / metabolism* superhelical / metabolism* multiprotein complexes / genetics multiprotein complexes / metabolism* protein kinases / metabolism*

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