Amantadine-oseltamivir combination therapy for H5N1 influenza virus infection in mice

Clicks: 264
ID: 274133
2007
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Abstract
Combination chemotherapy provided a survival advantage over single-agent treatment of mice inoculated with neurotropic H5N1 influenza virus. This strategy might be an option for the control of pandemic influenza viruses that are sensitive to amantadine. Combinations that include other drugs should b …
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Authors Ilyushina NA;Hoffmann E;Salomon R;Webster RG;Govorkova EA;;
Journal antiviral therapy
Year 2007
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/17591026
Keywords
Administration National Center for Biotechnology Information NCBI NLM MEDLINE Mice animals pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't female N.I.H. Extramural Inbred BALB C Viral drug resistance microbial sensitivity tests drug therapy combination dose-response relationship drug antiviral agents / administration & dosage antiviral agents / therapeutic use* oral drug evaluation antiviral agents / pharmacology influenza a virus preclinical orthomyxoviridae infections / drug therapy* orthomyxoviridae infections / virology amantadine / administration & dosage oseltamivir / therapeutic use* amantadine / pharmacology amantadine / therapeutic use* oseltamivir / administration & dosage pmid:17591026 natalia a ilyushina erich hoffmann elena a govorkova h5n1 subtype* / drug effects h5n1 subtype* / genetics oseltamivir / pharmacology

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