Granulocyte-macrophage colony-stimulating factor and interferon-gamma prevent dexamethasone-induced immunosuppression of antifungal monocyte activity against Aspergillus fumigatus hyphae

Clicks: 219
ID: 274027
1970
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Abstract
Treatment with corticosteroids is an important risk factor for development of invasive aspergillosis. We evaluated the effect of dexamethasone (DEX) on superoxide anion (O2-) release and damage caused by elutriated human monocytes (EHM) on unopsonized hyphae of Aspergillus fumigatus. In addition, we …
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Authors Roilides E;Blake C;Holmes A;Pizzo PA;Walsh TJ;;
Journal Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology
Year 1970
DOI
DOI not found
URL
https://www.ncbi.nlm.nih.gov/pubmed/8786473
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE humans pubmed abstract nih national institutes of health national library of medicine adult immunosuppression glucocorticoids / adverse effects monocytes / microbiology monocytes / metabolism granulocyte-macrophage colony-stimulating factor / pharmacology* monocytes / drug effects* aspergillus fumigatus / drug effects* e roilides t j walsh interferon-gamma / pharmacology* aspergillus fumigatus / growth & development dexamethasone / adverse effects pmid:8786473 c blake aspergillosis* / metabolism aspergillosis* / microbiology dexamethasone / antagonists & inhibitors* glucocorticoids / antagonists & inhibitors* superoxides / metabolism*

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