Exotoxin A-eEF2 complex structure indicates ADP ribosylation by ribosome mimicry

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ID: 273975
2005
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Abstract
The bacteria causing diphtheria, whooping cough, cholera and other diseases secrete mono-ADP-ribosylating toxins that modify intracellular proteins. Here, we describe four structures of a catalytically active complex between a fragment of Pseudomonas aeruginosa exotoxin A (ETA) and its protein subst …
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r2005natureexotoxin Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Jørgensen R;Merrill AR;Yates SP;Marquez VE;Schwan AL;Boesen T;Andersen GR;;
Journal Nature
Year 2005
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/16107839
Keywords
catalysis National Center for Biotechnology Information NCBI NLM MEDLINE Molecular pubmed abstract nih national institutes of health national library of medicine models research support non-u.s. gov't u.s. gov't non-p.h.s. protein conformation binding sites bacterial toxins / metabolism* exotoxins / metabolism* bacterial toxins / genetics exotoxins / genetics x-ray virulence factors / genetics crystallography nad / metabolism virulence factors / metabolism* rené jørgensen a rod merrill adp ribose transferases / genetics adp ribose transferases / metabolism* peptide elongation factor 2 / genetics peptide elongation factor 2 / metabolism* pseudomonas aeruginosa / chemistry pmid:16107839 doi:10.1038/nature03871 gregers r andersen adp ribose transferases / chemistry* adenosine diphosphate / metabolism* bacterial toxins / chemistry* exotoxins / chemistry* molecular mimicry* peptide elongation factor 2 / chemistry* ribose / metabolism* ribosomes / chemistry ribosomes / metabolism* saccharomyces cerevisiae virulence factors / chemistry*

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