Graphene quantum dots unraveling: Green synthesis, characterization, radiolabeling with 99mTc, in vivo behavior and mutagenicity.

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ID: 2739
2019
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Ranked #57 of 133 articles by views in materials science & engineering c, materials for biological applications

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Abstract
Graphene is one of the crystalline forms of carbon, along with diamond, graphite, carbon nanotubes, and fullerenes, and is considered as a revolutionary and innovating product. The use of a graphene-based nanolabels is one of the latest and most prominent application of graphene, especially in the field of diagnosis and, recently, in loco radiotherapy when coupled with radioisotopes. However, its biological behavior and mutagenicity in different cell or animal models, as well as the in vivo functional activities, are still unrevealed. In this study we have developed by a green route of synthesizing graphene quantum dots (GQDs) and characterized them. We have also developed a methodology for direct radiolabeling of GQDs with radioisotopes.Finally; we have evaluated in vivo biological behavior of GQDs using two different mice models and tested in vitro mutagenicity of GQDs. The results have shown that GQDs were formed with a size range of 160-280 nm, which was confirmed by DRX and Raman spectroscopy analysis, corroborating that the green synthesis is an alternative, environmentally friendly way to produce graphene. The radiolabeling test has shown that stable radiolabeled GQDs can be produced with a high yield (>90%). The in vivo test has demonstrated a ubiquitous behavior when administered to healthy animals, with a high uptake by liver (>26%) and small intestine (>25%). Otherwise, in an inflammation/VEGF hyperexpression animal model (endometriosis), a very peculiar behavior of GQDs was observed, with a high uptake by kidneys (over 85%). The mutagenicity test has demonstrated A:T to G:C substitutions suggesting that GQDs exhibits mutagenic activity.
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de-menezes2019graphenematerials Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors de Menezes, Frederico Duarte;Dos Reis, Sara Rhaissa Rezende;Pinto, Suyene Rocha;Portilho, Filipe Leal;do Vale Chaves E Mello, Francisco;Helal-Neto, Edward;da Silva de Barros, Aline Oliveira;Alencar, Luciana Magalhães Rebêlo;de Menezes, Alan Silva;Dos Santos, Clenilton Costa;Saraiva-Souza, Aldilene;Perini, Jamila Alessandra;Machado, Daniel Escorsim;Felzenswalb, Israel;Araujo-Lima, Carlos Fernando;Sukhanova, Alyona;Nabiev, Igor;Santos-Oliveira, Ralph;
Journal materials science & engineering c, materials for biological applications
Year 2019
DOI
S0928-4931(19)30086-4
URL
Keywords Keywords not found

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