Highly expressed loci are vulnerable to misleading ChIP localization of multiple unrelated proteins

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ID: 273875
2013
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Abstract
Chromatin immunoprecipitation (ChIP) is the gold-standard technique for localizing nuclear proteins in the genome. We used ChIP, in combination with deep sequencing (Seq), to study the genome-wide distribution of the Silent information regulator (Sir) complex in Saccharomyces cerevisiae. We analyzed …
Reference Key
l2013proceedingshighly Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Teytelman L;Thurtle DM;Rine J;van Oudenaarden A;;
Journal Proceedings of the National Academy of Sciences of the United States of America
Year 2013
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/24173036
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't u.s. gov't non-p.h.s. N.I.H. Extramural polymerase chain reaction high-throughput nucleotide sequencing artifacts* dna primers / genetics saccharomyces cerevisiae / genetics* pmid:24173036 pmc3831989 doi:10.1073/pnas.1316064110 leonid teytelman deborah m thurtle alexander van oudenaarden chromatin immunoprecipitation / methods* genetic loci / genetics* silent information regulator proteins

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