Spatiotemporal network alterations in experimental focal cortical epilepsy: MRI-based longitudinal functional connectivity and weighted graph analysis

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ID: 273800
2010
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Abstract
There is increasing evidence that the topology of brain networks may be changed in epilepsy. In particular, a random topology has been suggested as an explanation for lower seizure thresholds. To test this hypothesis, we assessed focal epileptic and healthy networks over time using resting state functional MRI and weighted graph theoretical analysis in a rat model. Brain networks in focal epilepsy were globally affected, toward a more ordered network topology. Networks largely normalized at ten weeks after epilepsy induction. Graph analysis provides a promising method to explore dynamical network alterations in epilepsy.
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braun20102010spatiotemporal Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors W.M. Otte,R.M. Dijkhuizen,C.J. Stam,K. Van Der Marel,M.P.A. Van Meer,M.A. Viergever,K.P.J. Braun;W.M. Otte;R.M. Dijkhuizen;C.J. Stam;K. Van Der Marel;M.P.A. Van Meer;M.A. Viergever;K.P.J. Braun;
Journal 2010 IEEE International Symposium on Biomedical Imaging: From Nano to Macro
Year 2010
DOI
10.1109/isbi.2010.5490129
URL
https://sciprofiles.com/publication/view/1937349f5a789aa8f29de6a7d5f9cb1b
Keywords
Magnetic resonance imaging epilepsy rats brain anesthesia network topology biomedical imaging animals spatiotemporal phenomena complex networks

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