ROCC, a conserved region in cohesin's Mcd1 subunit, is essential for the proper regulation of the maintenance of cohesion and establishment of condensation

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2014
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Abstract
Cohesin helps orchestrate higher-order chromosome structure, thereby promoting sister chromatid cohesion, chromosome condensation, DNA repair, and transcriptional regulation. To elucidate how cohesin facilitates these diverse processes, we mutagenized Mcd1p, the kleisin regulatory subunit of budding …
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Authors Eng T;Guacci V;Koshland D;;
Journal molecular biology of the cell
Year 2014
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/24966169
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE pubmed abstract nih national institutes of health national library of medicine research support u.s. gov't non-p.h.s. N.I.H. Extramural nuclear proteins / metabolism chromosomes cell cycle proteins / genetics cell cycle proteins / metabolism* saccharomyces cerevisiae / genetics* chromosomal proteins vincent guacci chromatids / genetics dna repair saccharomyces cerevisiae proteins / genetics saccharomyces cerevisiae proteins / metabolism* fungal non-histone / genetics non-histone / metabolism* doug koshland pmid:24966169 pmc4142609 doi:10.1091/mbc.e14-04-0929 thomas eng chromosome segregation

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