Integration of regulatory networks by NKX3-1 promotes androgen-dependent prostate cancer survival

Clicks: 254
ID: 273773
2012
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Abstract
The NKX3-1 gene is a homeobox gene required for prostate tumor progression, but how it functions is unclear. Here, using chromatin immunoprecipitation coupled to massively parallel sequencing (ChIP-seq) we showed that NKX3-1 colocalizes with the androgen receptor (AR) across the prostate cancer geno …
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py2012molecularintegration Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Tan PY;Chang CW;Chng KR;Wansa KD;Sung WK;Cheung E;;
Journal molecular and cellular biology
Year 2012
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/22083957
Keywords
Tumor National Center for Biotechnology Information NCBI NLM MEDLINE genetic gene expression regulation humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't male cell line neoplastic* Receptors Promoter Regions transcription factors / genetics* transcription factors / metabolism prostatic neoplasms / genetics* protein binding gene regulatory networks* transcriptional activation androgens / metabolism cell survival androgen / metabolism prostatic neoplasms / metabolism prostatic neoplasms / pathology chromatin immunoprecipitation prostate / metabolism prostate / pathology homeodomain proteins / metabolism transcription factors / analysis homeodomain proteins / genetics* androgen / analysis pmid:22083957 pmc3255774 doi:10.1128/mcb.05958-11 peck yean tan cheng wei chang edwin cheung hepatocyte nuclear factor 3-alpha / metabolism homeodomain proteins / analysis androgen / genetics* rab3 gtp-binding proteins / genetics

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