Integration of regulatory networks by NKX3-1 promotes androgen-dependent prostate cancer survival

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ID: 273773
2012
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Abstract
The NKX3-1 gene is a homeobox gene required for prostate tumor progression, but how it functions is unclear. Here, using chromatin immunoprecipitation coupled to massively parallel sequencing (ChIP-seq) we showed that NKX3-1 colocalizes with the androgen receptor (AR) across the prostate cancer geno …
Reference Key
py2012molecularintegration Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Tan PY, Chang CW, Chng KR, Wansa KD, Sung WK, Cheung E
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Journal molecular and cellular biology
Year 2012
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/22083957
Keywords
Tumor National Center for Biotechnology Information NCBI NLM MEDLINE genetic gene expression regulation humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't male cell line neoplastic* Receptors Promoter Regions transcription factors / genetics* transcription factors / metabolism prostatic neoplasms / genetics* protein binding gene regulatory networks* transcriptional activation androgens / metabolism cell survival androgen / metabolism prostatic neoplasms / metabolism prostatic neoplasms / pathology chromatin immunoprecipitation prostate / metabolism prostate / pathology homeodomain proteins / metabolism transcription factors / analysis homeodomain proteins / genetics* androgen / analysis pmid:22083957 pmc3255774 doi:10.1128/mcb.05958-11 peck yean tan cheng wei chang edwin cheung hepatocyte nuclear factor 3-alpha / metabolism homeodomain proteins / analysis androgen / genetics* rab3 gtp-binding proteins / genetics

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