The Use of Dopamine β-Hydroxylase as a Marker for the Central Noradrenergic Nervous System in Rat Brain

Clicks: 115
ID: 273702
1972
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Star

Ranked #37 of 50 articles by views in proceedings of the national academy of sciences

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Improvements in the method for localization of dopamine-β-hydroxylase by immunofluorescence allow the observation of noradrenergic-cell bodies, non-terminal fibers, and axon terminals in the rat brain. The distribution of the hydroxylase correlated well with the results obtained by localization of norepinephrine. Dopamine-β-hydroxylase was not observed in dopaminergic neurons or terminals, indicating that these cells do not have the capacity to synthesize norepinephrine. The use of the hydroxylase as a marker, however, has made it possible to visualize noradrenergic nerve terminals on small arteries in the brain parenchyma that have not been described by catecholamine-fluorescence histochemistry. The source of the terminals on small arteries appears to be central noradrenergic neurons rather than the peripheral sympathetic nervous system. Dopamine-β-hydroxylase generally was not observed in the large arteries of the brain parenchyma. These observations suggest that cerebral microcirculation is regulated by central noradrenergic neurons.
Reference Key
hartman1972proceedingsthe Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Boyd K. Hartman;Doris Zide;Sidney Udenfriend;Boyd K. Hartman;Doris Zide;Sidney Udenfriend;
Journal proceedings of the national academy of sciences
Year 1972
DOI
10.1073/pnas.69.9.2722
URL
https://doi.org/10.1073/pnas.69.9.2722
Keywords

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.