p53 and microRNA-34 are suppressors of canonical Wnt signaling

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ID: 273677
2011
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Abstract
Although loss of p53 function and activation of canonical Wnt signaling cascades are frequently coupled in cancer, the links between these two pathways remain unclear. We report that p53 transactivated microRNA-34 (miR-34), which consequently suppressed the transcriptional activity of β-catenin-T ce …
Reference Key
nh2011sciencep53 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Kim NH;Kim HS;Kim NG;Lee I;Choi HS;Li XY;Kang SE;Cha SY;Ryu JK;Na JM;Park C;Kim K;Lee S;Gumbiner BM;Yook JI;Weiss SJ;;
Journal science signaling
Year 2011
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=22045851
Keywords
Tumor National Center for Biotechnology Information NCBI NLM MEDLINE Mice animals humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't female N.I.H. Extramural Child Cells Cultured cell line Base Sequence mutation Gene Expression Regulation* gene expression profiling breast neoplasms / pathology embryo rna interference micrornas / metabolism hek293 cells beta catenin / metabolism micrornas / genetics* chick embryo tumor suppressor protein p53 / metabolism wnt1 protein / genetics wnt1 protein / metabolism 3' untranslated regions / genetics xenopus laevis breast neoplasms / genetics breast neoplasms / metabolism pmid:22045851 pmc3447368 doi:10.1126/scisignal.2001744 nam hee kim hyun sil kim stephen j weiss nonmammalian / embryology nonmammalian / metabolism neuroblastoma / genetics neuroblastoma / metabolism neuroblastoma / pathology tcf transcription factors / genetics tcf transcription factors / metabolism tumor suppressor protein p53 / genetics* wnt signaling pathway / genetics* beta catenin / genetics

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