Overexpression of HIF-2α, TWIST, and CXCR4 Is Associated with Lymph Node Metastasis in Papillary Thyroid Carcinoma
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ID: 273405
2013
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Abstract
This study aimed to examine HIF-2α, TWIST, and CXCR4 expression in papillary thyroid carcinoma (PTC) and assesses the association of their expression with clinicopathological indicators. HIF-2α, TWIST, and CXCR4 protein expression in 129 PTCs, 61 nodular hyperplasia, and 118 normal thyroid tissue specimens was analyzed using immunohistochemistry. The protein expression levels of these three molecules were upregulated in PTCs. High protein expression of HIF-2α, TWIST, and CXCR4 was significantly correlated with lymph node metastasis (LNM) (P
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| Reference Key |
liu2013clinicaloverexpression
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| Authors | Ni Wang,Hao-Jun Luo,Guo-Bing Yin,Chao-Ran Dong,Man Xu,George G. Chen,Zhi-Min Liu;Ni Wang;Hao-Jun Luo;Guo-Bing Yin;Chao-Ran Dong;Man Xu;George G. Chen;Zhi-Min Liu; |
| Journal | clinical and developmental immunology |
| Year | 2013 |
| DOI |
10.1155/2013/589423
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