Involvement of microRNAs in the cytotoxic effects exerted by proinflammatory cytokines on pancreatic beta-cells

Clicks: 272
ID: 273381
2010
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Abstract
Our data identify miR-21, miR-34a, and miR-146a as novel players in beta-cell failure elicited in vitro and in vivo by proinflammatory cytokines, notably during the development of peri-insulitis that precedes overt diabetes in NOD mice.
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Authors Roggli E;Britan A;Gattesco S;Lin-Marq N;Abderrahmani A;Meda P;Regazzi R;;
Journal Diabetes
Year 2010
DOI
DOI not found
URL
https://www.ncbi.nlm.nih.gov/pubmed/20086228
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice animals humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't female Cells Cultured cell line Genes polymerase chain reaction gene expression profiling oligonucleotide array sequence analysis inflammation / genetics lymphocytes / immunology lymphocytes / cytology reverse transcriptase polymerase chain reaction reporter cell death inbred nod inflammation / physiopathology micrornas / genetics* insulin-secreting cells / cytology insulin-secreting cells / physiology* lymphocytes / physiology pmid:20086228 pmc2844845 doi:10.2337/db09-0881 elodie roggli aurore britan romano regazzi cytokines / genetics* luciferases / genetics

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