Engineering Venom’s Toxin-Neutralizing Antibody Fragments and Its Therapeutic Potential

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ID: 273331
2014
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Abstract
Serum therapy remains the only specific treatment against envenoming, but anti-venoms are still prepared by fragmentation of polyclonal antibodies isolated from hyper-immunized horse serum. Most of these anti-venoms are considered to be efficient, but their production is tedious, and their use may be associated with adverse effects. Recombinant antibodies and smaller functional units are now emerging as credible alternatives and constitute a source of still unexploited biomolecules capable of neutralizing venoms. This review will be a walk through the technologies that have recently been applied leading to novel antibody formats with better properties in terms of homogeneity, specific activity and possible safety.
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alvarenga2014toxinsengineering Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Larissa M. Alvarenga;Muhammad Zahid;Anne Di Tommaso;Matthieu O. Juste;Nicolas Aubrey;Philippe Billiald;Julien Muzard;Alvarenga, Larissa M.;Zahid, Muhammad;Tommaso, Anne Di;Juste, Matthieu O.;Aubrey, Nicolas;Billiald, Philippe;Muzard, Julien;
Journal Toxins
Year 2014
DOI
10.3390/toxins6082541
URL
http://dx.doi.org/10.3390/toxins6082541
Keywords
antibody snakebite nanobody scorpion stings antivenom scfv serum therapy diabody

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