A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors

Clicks: 282
ID: 273316
1996
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Abstract
Nuclear receptors regulate gene expression by direct activation of target genes and inhibition of AP-1. Here we report that, unexpectedly, activation by nuclear receptors requires the actions of CREB-binding protein (CBP) and that inhibition of AP-1 activity is the apparent result of competition for …
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Authors Kamei Y;Xu L;Heinzel T;Torchia J;Kurokawa R;Gloss B;Lin SC;Heyman RA;Rose DW;Glass CK;Rosenfeld MG;;
Journal Cell
Year 1996
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/8616895
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Molecular animals pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't u.s. gov't conserved sequence P.H.S. Rats DNA Receptors Base Sequence Molecular Sequence Data ligands cytoplasmic and nuclear / genetics* cytoplasmic and nuclear / metabolism transcription factors / metabolism complementary / genetics sequence homology amino acid nuclear proteins / metabolism cloning binding sites / genetics molecular weight transcription factors / genetics gene expression regulation / genetics fibroblasts / physiology nuclear proteins / genetics creb-binding protein histone acetyltransferases nuclear receptor coactivator 1 trans-activators* m g rosenfeld binding transcription factors / pharmacology* pmid:8616895 doi:10.1016/s0092-8674(00)81118-6 y kamei l xu competitive / genetics nuclear proteins / pharmacology* transcription factor ap-1 / antagonists & inhibitors* transcriptional activation / drug effects*

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