Chromatin, TAFs, and a novel multiprotein coactivator are required for synergistic activation by Sp1 and SREBP-1a in vitro

Clicks: 243
ID: 273297
1998
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Abstract
The promoter selectivity factor Sp1 often cooperates with other enhancer-binding proteins to activate transcription. To study the molecular underpinnings of these regulatory events, we have reconstituted in vitro the synergy observed in vivo between Sp1 and the sterol-regulated factor SREBP-1a at th …
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Authors Näär AM;Beaurang PA;Robinson KM;Oliner JD;Avizonis D;Scheek S;Zwicker J;Kadonaga JT;Tjian R;;
Journal genes & development
Year 1998
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/9765204
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE genetic Drosophila animals humans pubmed abstract nih national institutes of health national library of medicine models research support non-u.s. gov't u.s. gov't P.H.S. Receptors DNA-Binding Proteins / physiology* Nuclear Proteins / physiology* Promoter Regions hela cells drug synergism transcription factors* sterol regulatory element binding protein 1 chromatin / physiology* ccaat-enhancer-binding proteins* LDL / genetics r tjian transcription factor tfiid transcriptional activation* pmid:9765204 pmc317191 doi:10.1101/gad.12.19.3020 a m näär p a beaurang helix-loop-helix motifs / physiology* leucine zippers / physiology* sp1 transcription factor / physiology* transcription factors tfii / physiology

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