Enforced c-KIT expression renders highly metastatic human melanoma cells susceptible to stem cell factor-induced apoptosis and inhibits their tumorigenic and metastatic potential

Clicks: 306
ID: 273283
1996
Free PDF
Article Quality & Performance Metrics
Overall Quality Improving Quality
0.0 /100
Combines engagement data with AI-assessed academic quality
AI Quality Assessment
Not analyzed
Abstract
Expression of the tyrosine-kinase receptor encoded by the c-KIT proto-oncogene progressively decreases during local tumor growth and invasion of human melanomas. To provide direct evidence that c-KIT plays a role in metastasis of human melanoma, we transfected the c-KIT gene into the c-KIT negative …
Reference Key
s1996oncogeneenforced Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Huang S;Luca M;Gutman M;McConkey DJ;Langley KE;Lyman SD;Bar-Eli M;;
Journal Oncogene
Year 1996
DOI
DOI not found
URL
https://www.ncbi.nlm.nih.gov/pubmed/8957075
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice RNA animals humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't u.s. gov't male P.H.S. Cultured phenotype Inbred BALB C messenger / metabolism nude skin neoplasms / genetics transfection tumor cells apoptosis* melanoma / genetics neoplasm proteins / genetics neoplasm proteins / metabolism* neoplasm transplantation skin neoplasms / pathology m luca pmid:8957075 s huang m bar-eli lung neoplasms / secondary* melanoma / metabolism* melanoma / pathology melanoma / secondary* proto-oncogene proteins c-kit / genetics proto-oncogene proteins c-kit / metabolism* skin neoplasms / metabolism* stem cell factor / metabolism stem cell factor / pharmacology*

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.