Enforced c-KIT expression renders highly metastatic human melanoma cells susceptible to stem cell factor-induced apoptosis and inhibits their tumorigenic and metastatic potential

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ID: 273283
1996
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Abstract
Expression of the tyrosine-kinase receptor encoded by the c-KIT proto-oncogene progressively decreases during local tumor growth and invasion of human melanomas. To provide direct evidence that c-KIT plays a role in metastasis of human melanoma, we transfected the c-KIT gene into the c-KIT negative …
Reference Key
s1996oncogeneenforced Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Huang S, Luca M, Gutman M, McConkey DJ, Langley KE, Lyman SD, Bar-Eli M
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Journal Oncogene
Year 1996
DOI
DOI not found
URL
https://www.ncbi.nlm.nih.gov/pubmed/8957075
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice RNA animals humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't u.s. gov't male P.H.S. Cultured phenotype Inbred BALB C messenger / metabolism nude skin neoplasms / genetics transfection tumor cells apoptosis* melanoma / genetics neoplasm proteins / genetics neoplasm proteins / metabolism* neoplasm transplantation skin neoplasms / pathology m luca pmid:8957075 s huang m bar-eli lung neoplasms / secondary* melanoma / metabolism* melanoma / pathology melanoma / secondary* proto-oncogene proteins c-kit / genetics proto-oncogene proteins c-kit / metabolism* skin neoplasms / metabolism* stem cell factor / metabolism stem cell factor / pharmacology*

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