Zur Pathogenese und Therapie des Waterhouse-Friderichsen-Syndroms*
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ID: 273271
1968
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Abstract
Anhand von tierexperimentellen Untersuchungen wird zum Problem der Entstehung und Therapie des Waterhouse-Friderichsen-Syndroms Stellung genommen. Allein die Gabe von Corticoiden in sehr hoher Dosis (Prednisolon bis 25 mg/kg täglich) im Frühstadium des Krankheitsverlaufes erscheint erfolgversprechend. Die Befürchtung, durch Nebennierenrindensteroide ein Sanarelli-Shwartzman-Phänomen auszulösen oder zu verstärken, ist unbegründet. Animal experiments were performed to study various problems connected with the development and treatment of Waterhouse-Friderichsen's syndrome. Very high doses of corticoids (prednisolone up to 24 mg./kg. daily) in the early stage of the syndrome may well cause a favourable response. There is no justification for fearing that adrenal steroids may precipitate a Sanarelli-Shwartzman phenomenon or accentuate it. Acerca de la patogénesis y tratamiento del síndrome de Waterhouse-Friderichsen A base de los estudios de experimentación animal se enjuicia el desarrollo y el tratamiento del síndrome de Waterhouse-Friderichsen. La administración aislada de corticoides en dosis muy altas (hasta 25 mg/Kg diarios) en los estadios iniciales de la evolución clínica parecen prometedores. El temor de desencadenar o intensificar un fenómeno de Sanarelli-Shwartzman por los esteroides de la corteza suprarrenal carece de fundamento.
| Reference Key |
(wolfram)1968dmwzur
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|---|---|
| Authors | J. Dieckhoff,J. Bartel,E. Hoppe (Wolfram);J. Dieckhoff;J. Bartel;E. Hoppe (Wolfram); |
| Journal | DMW - Deutsche Medizinische Wochenschrift |
| Year | 1968 |
| DOI |
10.1055/s-0028-1110751
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| URL | |
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