Zur Pathogenese und Therapie des Waterhouse-Friderichsen-Syndroms*

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ID: 273271
1968
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Abstract
Anhand von tierexperimentellen Untersuchungen wird zum Problem der Entstehung und Therapie des Waterhouse-Friderichsen-Syndroms Stellung genommen. Allein die Gabe von Corticoiden in sehr hoher Dosis (Prednisolon bis 25 mg/kg täglich) im Frühstadium des Krankheitsverlaufes erscheint erfolgversprechend. Die Befürchtung, durch Nebennierenrindensteroide ein Sanarelli-Shwartzman-Phänomen auszulösen oder zu verstärken, ist unbegründet. Animal experiments were performed to study various problems connected with the development and treatment of Waterhouse-Friderichsen's syndrome. Very high doses of corticoids (prednisolone up to 24 mg./kg. daily) in the early stage of the syndrome may well cause a favourable response. There is no justification for fearing that adrenal steroids may precipitate a Sanarelli-Shwartzman phenomenon or accentuate it. Acerca de la patogénesis y tratamiento del síndrome de Waterhouse-Friderichsen A base de los estudios de experimentación animal se enjuicia el desarrollo y el tratamiento del síndrome de Waterhouse-Friderichsen. La administración aislada de corticoides en dosis muy altas (hasta 25 mg/Kg diarios) en los estadios iniciales de la evolución clínica parecen prometedores. El temor de desencadenar o intensificar un fenómeno de Sanarelli-Shwartzman por los esteroides de la corteza suprarrenal carece de fundamento.
Reference Key
(wolfram)1968dmwzur Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors J. Dieckhoff,J. Bartel,E. Hoppe (Wolfram);J. Dieckhoff;J. Bartel;E. Hoppe (Wolfram);
Journal DMW - Deutsche Medizinische Wochenschrift
Year 1968
DOI
10.1055/s-0028-1110751
URL
https://sciprofiles.com/publication/view/dcbe6dae078468c027b3ba24b3745332
Keywords
animal treatment waterhouse friderichsen dosis mg/kg corticoides sanarelli

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