Fishing of α-Glucosidase's Ligands from by α-Glucosidase Functionalized Magnetic Nanoparticles.

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ID: 273235
2021
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Abstract
α-Glucosidase was immobilized on magnetic nanoparticles (MNPs) for selective solid-phase extraction of the enzyme's ligands present in , which is a medicinal plant used for the treatment of various diseases and possesses anti-diabetic activity. One new compound, aloeacone (), together with two known compounds, aloenin aglycone () and aloin A (), were fished out as the enzyme's ligands. The structure of was determined by HR-MS and comprehensive NMR techniques. Compound exhibited a weak inhibitory effect on α-glucosidase, while compounds and were found to possess activation effects on the enzyme for the first time. It is interesting that both an inhibitor and agonists of α-glucosidase were fished out in one experiment.
Reference Key
yuan2021fishingmolecules Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Yuan, Hao;Wan, Hong;Hu, Yi-Kao;Ayeni, Emmanuel Ayodeji;Chang, Qiang;Ma, Chao;Liao, Xun;
Journal molecules
Year 2021
DOI
5840
URL
Keywords
magnetic nanoparticles α-glucosidase aloe vera ligand fishing

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