A luminal epithelial stem cell that is a cell of origin for prostate cancer - Nature

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ID: 273228
2009
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Abstract
A known regulator of prostate epithelial differentiation, Nkx3-1, is shown here to mark a stem cell population that functions during prostate regeneration. Furthermore, in mice in which the Pten tumour suppressor gene is deleted in a group of rare cells that express Nkx3-1 in the absence of testicular androgens, termed CARN cells, there is rapid carcinoma formation after andogen-mediated regeneration. These observations indicate that prostate cancer can originate in CARN cells.
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xi2009naturea Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Wang, Xi;Julio, Marianna Kruithof-de;Economides, Kyriakos D.;Walker, David;Yu, Hailong;Halili, M. Vivienne;Hu, Ya-Ping;Price, Sandy M.;Abate-Shen, Cory;Shen, Michael M.;Wang, Xi;Julio, Marianna Kruithof-de;Economides, Kyriakos D.;Walker, David;Yu, Hailong;Halili, M. Vivienne;Hu, Ya-Ping;Price, Sandy M.;Abate-Shen, Cory;Shen, Michael M.;
Journal Nature
Year 2009
DOI
doi:10.1038/nature08361
URL
http://dx.doi.org/10.1038/nature08361
Keywords
Science humanities and social sciences multidisciplinary

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