Inflammatory mediators and islet beta-cell failure: a link between type 1 and type 2 diabetes

Clicks: 257
ID: 273226
2003
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Abstract
Pancreatic islet beta-cell death occurs in type 1 and 2 diabetes mellitus, leading to absolute or relative insulin deficiency. beta-cell death in type 1 diabetes is due predominantly to autoimmunity. In type 2 diabetes beta-cell death occurs as the combined consequence of increased circulating gluco …
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Authors Donath MY;Størling J;Maedler K;Mandrup-Poulsen T;;
Journal journal of molecular medicine (berlin, germany)
Year 2003
DOI
DOI not found
URL
https://www.ncbi.nlm.nih.gov/pubmed/12879149
Keywords
immunity National Center for Biotechnology Information NCBI NLM MEDLINE review animals humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't Adipocytes / metabolism Active glucose / metabolism apoptosis diabetes mellitus cytokines / metabolism cytokines / biosynthesis innate type 2 / physiopathology* insulin resistance autoimmunity type 2 / immunology marc y donath type 1 / etiology type 1 / immunology pmid:12879149 doi:10.1007/s00109-003-0450-y joachim størling thomas mandrup-poulsen type 1 / physiopathology* type 2 / etiology inflammation mediators / physiology* islets of langerhans / physiopathology*

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