IL-10 deficiency unleashes an influenza-specific Th17 response and enhances survival against high-dose challenge

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ID: 273216
2009
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Abstract
We examined the expression and influence of IL-10 during influenza infection. We found that IL-10 does not impact sublethal infection, heterosubtypic immunity, or the maintenance of long-lived influenza Ag depots. However, IL-10-deficient mice display dramatically increased survival compared with wi …
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Authors McKinstry KK;Strutt TM;Buck A;Curtis JD;Dibble JP;Huston G;Tighe M;Hamada H;Sell S;Dutton RW;Swain SL;;
Journal Journal of immunology (Baltimore, Md. : 1950)
Year 2009
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/19494257
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice animals pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't u.s. gov't non-p.h.s. N.I.H. Extramural Antigens orthomyxoviridae infections / immunology* survival rate viral / immunology t-lymphocytes helper-inducer / immunology* influenza a virus interleukin-10 / metabolism h1n1 subtype / immunology* interleukin-17 / immunology* interleukin-10 / genetics interleukin-10 / immunology* pmid:19494257 pmc2724021 doi:10.4049/jimmunol.0900657 k kai mckinstry tara m strutt susan l swain forkhead transcription factors / immunology interleukin-10 / deficiency* orthomyxoviridae infections / genetics orthomyxoviridae infections / metabolism

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