PRDM16 controls a brown fat/skeletal muscle switch

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ID: 273104
2008
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Abstract
Brown fat can increase energy expenditure and protect against obesity through a specialized program of uncoupled respiration. Here we show by in vivo fate mapping that brown, but not white, fat cells arise from precursors that express Myf5, a gene previously thought to be expressed only in the myoge …
Reference Key
p2008natureprdm16 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Seale P;Bjork B;Yang W;Kajimura S;Chin S;Kuang S;Scimè A;Devarakonda S;Conroe HM;Erdjument-Bromage H;Tempst P;Rudnicki MA;Beier DR;Spiegelman BM;;
Journal Nature
Year 2008
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/18719582
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice gene expression regulation animals pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't male N.I.H. Extramural cell line DNA-Binding Proteins / metabolism* Transcription Factors / metabolism* adipose tissue white / metabolism developmental* chlorocebus aethiops skeletal / cytology dna-binding proteins / genetics transcription factors / genetics ppar gamma / genetics muscle bruce m spiegelman skeletal / metabolism* cos cells pmid:18719582 pmc2583329 doi:10.1038/nature07182 patrick seale bryan bjork adipocytes brown / cytology brown / metabolism* cell differentiation* / genetics muscle development / genetics skeletal / growth & development myogenic regulatory factor 5 / genetics

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