Activation of cAMP and mitogen responsive genes relies on a common nuclear factor

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ID: 273044
1994
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Abstract
A number of signalling pathways stimulate transcription of target genes through nuclear factors whose activities are primarily regulated by phosphorylation. Cyclic AMP regulates the expression of numerous genes, for example, through the protein kinase-A (PKA)-mediated phosphorylation of transcriptio …
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Authors Arias J;Alberts AS;Brindle P;Claret FX;Smeal T;Karin M;Feramisco J;Montminy M;;
Journal Nature
Year 1994
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/8028671
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE genetic Mice animals humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't u.s. gov't amino acid sequence P.H.S. signal transduction* Genes 3T3 Cells Nuclear Proteins / metabolism* Transcription Factors / metabolism* Molecular Sequence Data Gene Expression Regulation* Promoter Regions transcription blotting western hela cells rabbits phosphorylation reporter creb-binding protein trans-activators* cyclic amp response element-binding protein / metabolism proto-oncogene proteins c-jun / genetics Nuclear Proteins / immunology m montminy serine / metabolism pmid:8028671 doi:10.1038/370226a0 j arias a s alberts cyclic amp / metabolism* mitogens / metabolism* transcription factors / immunology

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