Association between the perturbation of bile acid homeostasis and valproic acid-induced hepatotoxicity

Clicks: 234
ID: 272717
2019
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Abstract
Valproic acid (VPA), a widely prescribed antiepileptic drug, is known to induce hepatotoxicity. However, the mechanisms underlying this toxicity are not well understood. In this study, we performed a nontargeted metabolomic analysis of children with epilepsy treated with VPA (n = 23). Metabolic path …
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Authors Chen Y;Zhou J;Xu S;Liu M;Wang M;Ma Y;Zhao M;Wang Z;Guo Y;Zhao L;;
Journal biochemical pharmacology
Year 2019
DOI
DOI not found
URL
https://www.pubmed.gov/31628911/
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice Inbred C57BL animals humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't female male adolescent Child Infant preschool Liver / metabolism* lipid metabolism / drug effects homeostasis / physiology homeostasis / drug effects* pmid:31628911 doi:10.1016/j.bcp.2019.113669 yanan chen jingkai zhou limei zhao anticonvulsants / toxicity* bile acids and salts / metabolism* lipid metabolism / physiology liver / drug effects* metabolomics / methods valproic acid / toxicity*

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