An extracellular steric seeding mechanism for Eph-ephrin signaling platform assembly - Nature Structural & Molecular Biology

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ID: 272692
2010
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Abstract
Eph receptors are cell surface protein tyrosine kinases that mediate cell-cell communication. The crystal structure of the full ectodomain of unliganded human EphA2 (eEphA2) reveals that it forms linear arrays of staggered, parallel receptors, whereas that of eEphA2 in complex with ephrinA5 forms a more elaborate assembly with interfaces that are crucial for localization at cell-cell contacts and for activation-dependent degradation.
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Authors Seiradake, Elena;Harlos, Karl;Sutton, Geoff;Aricescu, A Radu;Jones, E Yvonne;Seiradake, Elena;Harlos, Karl;Sutton, Geoff;Aricescu, A Radu;Jones, E Yvonne;
Journal Nature structural & molecular biology
Year 2010
DOI
doi:10.1038/nsmb.1782
URL
https://doi.org/10.1038/nsmb.1782
Keywords
structural biology cell signalling kinases

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