Olefin cyclopropanation via carbene transfer catalyzed by engineered cytochrome P450 enzymes

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ID: 272653
2013
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Abstract
Transition metal-catalyzed transfers of carbenes, nitrenes, and oxenes are powerful methods for functionalizing C=C and C-H bonds. Nature has evolved a diverse toolbox for oxene transfers, as exemplified by the myriad monooxygenation reactions catalyzed by cytochrome P450 enzymes. The isoelectronic …
Reference Key
ps2013scienceolefin Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Coelho PS;Brustad EM;Kannan A;Arnold FH;;
Journal Science (New York, N.Y.)
Year 2013
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=23258409
Keywords
catalysis National Center for Biotechnology Information NCBI NLM MEDLINE pubmed abstract nih national institutes of health national library of medicine models research support non-u.s. gov't u.s. gov't non-p.h.s. N.I.H. Extramural chemical stereoisomerism methane / analogs & derivatives* methane / chemistry protein engineering pmid:23258409 doi:10.1126/science.1231434 pedro s coelho eric m brustad frances h arnold alkenes / chemistry* bacillus megaterium / enzymology cyclopropanes / chemistry* cytochrome p-450 enzyme system / chemistry* cytochrome p-450 enzyme system / genetics

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