Imaging of single cell responses to ER stress indicates that the relative dynamics of IRE1/XBP1 and PERK/ATF4 signalling rather than a switch between signalling branches determine cell survival

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ID: 272573
2015
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Abstract
An accumulation of misfolded proteins in the endoplasmic reticulum (ER) triggers the unfolded protein response (UPR) mediated via the activation of three transmembrane proteins IRE1, PERK and ATF6. Signalling through these proteins is aimed at enhancing the ER folding capacity and reducing the foldi …
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Authors Walter F;Schmid J;Düssmann H;Concannon CG;Prehn JH;;
Journal Cell death and differentiation
Year 2015
DOI
DOI not found
URL
https://www.pubmed.gov/25633195/
Keywords
Tumor National Center for Biotechnology Information NCBI NLM MEDLINE humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't cell line DNA-Binding Proteins / metabolism* Transcription Factors / metabolism* signal transduction protein-serine-threonine kinases / metabolism* endoribonucleases / metabolism* apoptosis / physiology membrane proteins / metabolism* regulatory factor x transcription factors x-box binding protein 1 cell survival / physiology pmid:25633195 pmc4532775 doi:10.1038/cdd.2014.241 f walter j schmid j h m prehn activating transcription factor 4 / metabolism* endoplasmic reticulum stress / physiology* single-cell analysis / methods unfolded protein response eif-2 kinase / metabolism*

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