Systemic antibodies towards mucosal bacteria in ulcerative colitis and Crohn's disease differentially activate the innate immune response

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ID: 272552
2004
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Abstract
Changes in mucosal bacteria, and a switch from internal to surface antigen/antibody reactivity of a predominantly IgG1 type, leads to greater opsonisation of the respiratory burst in PMN, providing a mechanism for maintaining the inflammatory state in UC.
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Authors Furrie E;Macfarlane S;Cummings JH;Macfarlane GT;;
Journal Gut
Year 2004
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/14684582
Keywords
immunity National Center for Biotechnology Information NCBI NLM MEDLINE humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't female male aged middle aged 80 and over Antibodies Antigens Bacteria / isolation & purification* intestinal mucosa / immunology intestinal mucosa / microbiology* Colitis immunoglobulin g / blood bacterial / immunology* bacterial / blood bacterial / immunology surface / immunology neutrophils / immunology g t macfarlane ulcerative / microbiology immunoglobulin a / blood bacteria / immunology rectum / microbiology crohn disease / microbiology ulcerative / immunology* pmid:14684582 pmc1773925 doi:10.1136/gut.53.1.91 e furrie s macfarlane crohn disease / immunology* mucosal rectum / immunology respiratory burst

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