A luminal epithelial stem cell that is a cell of origin for prostate cancer

Clicks: 277
ID: 272549
2009
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Abstract
In epithelial tissues, the lineage relationship between normal progenitor cells and cell type(s) of origin for cancer has been poorly understood. Here we show that a known regulator of prostate epithelial differentiation, the homeobox gene Nkx3-1, marks a stem cell population that functions during p …
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Authors Wang X;Kruithof-de Julio M;Economides KD;Walker D;Yu H;Halili MV;Hu YP;Price SM;Abate-Shen C;Shen MM;;
Journal Nature
Year 2009
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/19741607
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice Inbred C57BL Kidney gene expression regulation animals pubmed abstract nih national institutes of health national library of medicine research support u.s. gov't non-p.h.s. male N.I.H. Extramural transcription factors / metabolism cell differentiation nude transcription factors / genetics cell transformation neoplastic epithelial cells / metabolism cell division pten phosphohydrolase / genetics androgens / metabolism castration prostatic neoplasms / metabolism prostatic neoplasms / pathology* prostatic neoplasms / genetics epithelial cells / pathology* homeodomain proteins / metabolism cell lineage* regeneration homeodomain proteins / genetics pmid:19741607 pmc2800362 doi:10.1038/nature08361 xi wang marianna kruithof-de julio michael m shen androgens / deficiency epithelial cells / transplantation neoplastic stem cells / metabolism neoplastic stem cells / pathology* neoplastic stem cells / transplantation pten phosphohydrolase / deficiency

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