Wnt5a inhibits canonical Wnt signaling in hematopoietic stem cells and enhances repopulation

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ID: 272537
2007
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Abstract
The mechanisms that regulate hematopoietic stem cell (HSC) fate decisions between proliferation and multilineage differentiation are unclear. Members of the Wnt family of ligands that activate the canonical Wnt signaling pathway, which utilizes β-catenin to relay the signal, have been demonstrated to regulate HSC function. In this study, we examined the role of noncanonical Wnt signaling in regulating HSC fate. We observed that noncanonical Wnt5a inhibited Wnt3a-mediated canonical Wnt signaling in HSCs and suppressed Wnt3a-mediated alterations in gene expression associated with HSC differentiation, such as increased expression of myc . Wnt5a increased short- and long-term HSC repopulation by maintaining HSCs in a quiescent G state. From these data, we propose that Wnt5a regulates hematopoiesis by the antagonism of the canonical Wnt pathway, resulting in a pool of quiescent HSCs.
Reference Key
nemeth2007proceedingswnt5a Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Michael J. Nemeth;Lilia Topol;Stacie M. Anderson;Yingzi Yang;David M. Bodine;Michael J. Nemeth;Lilia Topol;Stacie M. Anderson;Yingzi Yang;David M. Bodine;
Journal proceedings of the national academy of sciences
Year 2007
DOI
10.1073/pnas.0704747104
URL
https://doi.org/10.1073/pnas.0704747104
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