Chloroquine antagonizes the proinflammatory cytokine response to opportunistic fungi by alkalizing the fungal phagolysosome

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ID: 272478
2001
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Abstract
Recent observations demonstrated that the antimalarial drug chloroquine (CQ) can kill the opportunistic fungus Cryptococcus neoformans. Since CQ blunts lipopolysaccharide (LPS)-induced tumor necrosis factor (TNF)-alpha release, it was hypothesized that this drug would also interfere with the inflamm …
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sm2001thechloroquine Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Weber SM;Levitz SM;;
Journal The Journal of infectious diseases
Year 2001
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/11237811
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't u.s. gov't P.H.S. Cells Cultured genetic / drug effects transcription enzyme inhibitors / pharmacology anti-bacterial agents / pharmacology leukocytes mononuclear / immunology cell survival / drug effects cytokines / biosynthesis cell nucleus / metabolism nf-kappa b / metabolism hiv seropositivity / immunology* cell nucleus tumor necrosis factor-alpha / biosynthesis* tumor necrosis factor-alpha / genetics chloroquine / pharmacology* s m levitz pmid:11237811 doi:10.1086/319259 s m weber active transport ammonium chloride / pharmacology candida albicans / immunology* cryptococcus neoformans / immunology* endosomes / drug effects hydrogen-ion concentration / drug effects lysosomes / drug effects* macrolides*

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