Conditional gene targeting in mouse pancreatic ß-Cells: analysis of ectopic Cre transgene expression in the brain

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ID: 272472
2010
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Abstract
Cre-mediated gene manipulation using transgenic lines that express Cre under the control of the Ins2 and Pdx1 promoters are likely to alter gene expression in nutrient-sensing neurons. Therefore, data arising from the use of these transgenic Cre lines must be interpreted carefully to assess whether …
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Authors Wicksteed B;Brissova M;Yan W;Opland DM;Plank JL;Reinert RB;Dickson LM;Tamarina NA;Philipson LH;Shostak A;Bernal-Mizrachi E;Elghazi L;Roe MW;Labosky PA;Myers MG;Gannon M;Powers AC;Dempsey PJ;;
Journal Diabetes
Year 2010
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/20802254
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE genetic Mice animals pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't u.s. gov't non-p.h.s. female male N.I.H. Extramural Genes Crosses immunohistochemistry transgenic swine reverse transcriptase polymerase chain reaction immunoglobulin g insulin-secreting cells / physiology* integrases / genetics* gene targeting / methods* brain / physiology pmid:20802254 pmc2992770 doi:10.2337/db10-0624 barton wicksteed marcela brissova peter j dempsey estrogen antagonists / pharmacology galactosides / metabolism reporter / genetics insulin / immunology leptin / pharmacology tamoxifen / pharmacology*

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