In vitro and in vivo evaluation of degradation, toxicity, biodistribution, and clearance of silica nanoparticles as a function of size, porosity, density, and composition

Clicks: 239
ID: 272360
2019
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Abstract
Silica nanoparticles (SiO2 NPs) have potential utility in controlled release. Despite significant research in this area, there is a gap in the understanding of the correlation between SiO2 NP physicochemical properties on the one hand and their degradation in solutions, in cell …
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Authors Hadipour Moghaddam SP;Mohammadpour R;Ghandehari H;;
Journal Journal of controlled release : official journal of the Controlled Release Society
Year 2019
DOI
DOI not found
URL
https://www.ncbi.nlm.nih.gov/pubmed/31465825
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice animals humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't female N.I.H. Extramural cell line particle size osmolar concentration hydrogen-ion concentration cell survival / drug effects feces / chemistry tissue distribution porosity silicon dioxide / chemistry pmid:31465825 pmc6874921 doi:10.1016/j.jconrel.2019.08.028 seyyed pouya hadipour moghaddam raziye mohammadpour hamidreza ghandehari aorta / cytology endothelial cells / drug effects gastric juice / chemistry intestinal secretions / chemistry lysosomes / chemistry nanoparticles / administration & dosage* nanoparticles / chemistry nanoparticles / toxicity silicon dioxide / administration & dosage* silicon dioxide / toxicity silicon dioxide / urine

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