Dissolution of bupivacaine 3-hydroxy-2-naphthoate into phosphate buffers
Clicks: 329
ID: 272178
1979
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
Popular Article
30.0
/100
329 views
58 readers
AI Quality Assessment
Not analyzed
Readership in this journal
PopularRanked #1 of 5 articles by views in Journal of Pharmacy and Pharmacology
Most read
Least read
Bar heights use a square-root scale.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
Dissolution behaviour of bupivacaine 3-hydroxy-2-naphthoate (BUPNH) into phosphate buffers, pH 7·4 was investigated at 25° and 37°C. Although the dissolution pattern of the salt at 25°C was normal, i.e. the concentrations of the acid and base component agreed, during the entire dissolution period, that at 37°C was anomalous. The dissolution consisted of two phases, i.e. an initial normal phase was followed by a second slower phase in which the concentration of the acid became, at equilibrium, markedly higher than that of the base. This unusual dissolution behaviour at 37°C was shown to be due to the precipitation of the base, which, in turn, is attributed to the unusual temperature dependency of the solubility of the base in phosphate buffers, i.e. decrease in solubility with increasing temperature.
| Reference Key |
setoya1979journaldissolution
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | Naomi I. Nakano,Akiko Setoya;Naomi I. Nakano;Akiko Setoya; |
| Journal | Journal of Pharmacy and Pharmacology |
| Year | 1979 |
| DOI |
10.1111/j.2042-7158.1979.tb13605.x
|
| URL | |
| Keywords |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.