Dissolution of bupivacaine 3-hydroxy-2-naphthoate into phosphate buffers
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1979
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Abstract
Dissolution behaviour of bupivacaine 3-hydroxy-2-naphthoate (BUPNH) into phosphate buffers, pH 7·4 was investigated at 25° and 37°C. Although the dissolution pattern of the salt at 25°C was normal, i.e. the concentrations of the acid and base component agreed, during the entire dissolution period, that at 37°C was anomalous. The dissolution consisted of two phases, i.e. an initial normal phase was followed by a second slower phase in which the concentration of the acid became, at equilibrium, markedly higher than that of the base. This unusual dissolution behaviour at 37°C was shown to be due to the precipitation of the base, which, in turn, is attributed to the unusual temperature dependency of the solubility of the base in phosphate buffers, i.e. decrease in solubility with increasing temperature.
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| Authors | Naomi I. Nakano,Akiko Setoya;Naomi I. Nakano;Akiko Setoya; |
| Journal | Journal of Pharmacy and Pharmacology |
| Year | 1979 |
| DOI |
10.1111/j.2042-7158.1979.tb13605.x
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