Evidence that microRNAs are associated with translating messenger RNAs in human cells - Nature Structural & Molecular Biology

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ID: 271989
2006
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Abstract
MicroRNAs (miRNAs) regulate gene expression post-transcriptionally by binding the 3′ untranslated regions of target mRNAs. We examined the subcellular distribution of three miRNAs in exponentially growing HeLa cells and found that the vast majority are associated with mRNAs in polysomes. Several lines of evidence indicate that most of these mRNAs, including a known miRNA-regulated target (KRAS mRNA), are actively being translated.
Reference Key
a2006natureevidence Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Maroney, Patricia A;Yu, Yang;Fisher, Jesse;Nilsen, Timothy W;Maroney, Patricia A;Yu, Yang;Fisher, Jesse;Nilsen, Timothy W;
Journal Nature structural & molecular biology
Year 2006
DOI
doi:10.1038/nsmb1174
URL
https://dx.doi.org/10.1038/nsmb1174
Keywords
biochemistry protein structure life sciences general biological microscopy membrane biology

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