Prostate tumor progression is mediated by a paracrine TGF-β/Wnt3a signaling axis - Oncogene
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ID: 271799
2008
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Abstract
Transforming growth factor (TGF)-β is an important paracrine factor in tumorigenesis. Ligand binding of the type I and II TGF-β receptors initiate downstream signaling. The role of stromal TGF-β signaling in prostate cancer progression is unknown. In mice, the conditional stromal knockout of the TGF-β type II receptor expression (Tgfbr2fspKO) resulted in the development of prostatic intraepithelial neoplasia and progression to adenocarcinoma within 7 months. Clinically, we observed a loss of TGF-β receptor type II expression in 69% of human prostate cancer-associated stroma, compared to 15% of stroma associated with benign tissues (n=140, P-value
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| Reference Key |
x2008oncogeneprostate1
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| Authors | Li, X;Placencio, V;Iturregui, J M;Uwamariya, C;Sharif-Afshar, A-R;Koyama, T;Hayward, S W;Bhowmick, N A;Li, X;Placencio, V;Iturregui, J M;Uwamariya, C;Sharif-Afshar, A-R;Koyama, T;Hayward, S W;Bhowmick, N A; |
| Journal | Oncogene |
| Year | 2008 |
| DOI |
doi:10.1038/onc.2008.293
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| URL | |
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