Hereditary Diffuse Gastric Cancer: Prophylactic Surgical Oncology Implications

Clicks: 260
ID: 271715
2008
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Abstract
Hereditary diffuse gastric cancer (HDGC) is an autosomal dominantly inherited syndrome attributed to mutations of the E-cadherin gene, CDH1. There is no proven effective screening for early HDGC, and symptomatic disease is almost universally fatal. The only available effective option for CDH1 carriers is prophylactic total gastrectomy, but the variable age of onset of HDGC and the reduced penetrance (about 70%) of the CDHI gene further complicate patients' decision making.
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huntsman2008surgicalhereditary Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Henry T. Lynch,Edibaldo Silva,Debrah Wirtzfeld,Pamela Hebbard,Jane Lynch,David G. Huntsman;Henry T. Lynch;Edibaldo Silva;Debrah Wirtzfeld;Pamela Hebbard;Jane Lynch;David G. Huntsman;
Journal surgical clinics of north america
Year 2008
DOI
10.1016/j.suc.2008.04.006
URL
https://sciprofiles.com/publication/view/6715cd796630d2f3b9c47f53f18d0589
Keywords
oncology decision making gastric cancer hereditary penetrance cadherin hdgc diffuse gastric cdhi

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