Assignment of the membrane attachment, DNA binding, and transcriptional activation domains of sterol regulatory element-binding protein-1 (SREBP-1)

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ID: 271707
1994
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Abstract
Transcription of the low density lipoprotein receptor gene and other sterol-regulated genes is stimulated by sterol regulatory element-binding protein-1 (SREBP-1), a basic-helix-loop-helix-leucine zipper (bHLH-ZIP) transcription factor. Human SREBP-1 is synthesized as an 1147-amino acid precursor th …
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Authors Sato R;Yang J;Wang X;Evans MJ;Ho YK;Goldstein JL;Brown MS;;
Journal The Journal of biological chemistry
Year 1994
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/8006035
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE gene expression regulation animals humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't u.s. gov't amino acid sequence sequence alignment Comparative Study P.H.S. DNA-Binding Proteins / metabolism* Nuclear Proteins / metabolism* Transcription Factors / metabolism* Molecular Sequence Data sequence homology amino acid cricetinae solubility structure-activity relationship mutagenesis sterol regulatory element binding protein 1 nuclear proteins / chemistry m s brown ccaat-enhancer-binding proteins* site-directed cell compartmentation j yang membrane proteins / metabolism* r sato pmid:8006035

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