Minor class splicing shapes the zebrafish transcriptome during development

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ID: 271618
2014
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Abstract
Minor class or U12-type splicing is a highly conserved process required to remove a minute fraction of introns from human pre-mRNAs. Defects in this splicing pathway have recently been linked to human disease, including a severe developmental disorder encompassing brain and skeletal abnormalities kn …
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Authors Markmiller S;Cloonan N;Lardelli RM;Doggett K;Keightley MC;Boglev Y;Trotter AJ;Ng AY;Wilkins SJ;Verkade H;Ober EA;Field HA;Grimmond SM;Lieschke GJ;Stainier DY;Heath JK;;
Journal Proceedings of the National Academy of Sciences of the United States of America
Year 2014
DOI
DOI not found
URL
https://www.pubmed.gov/24516132/
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE RNA gene expression regulation animals pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't N.I.H. Extramural Sequence Analysis Base Sequence Molecular Sequence Data gene expression profiling zebrafish / genetics* zebrafish proteins / genetics* developmental / physiology* real-time polymerase chain reaction developmental / genetics microarray analysis protein conformation* pmid:24516132 pmc3939875 doi:10.1073/pnas.1305536111 sebastian markmiller nicole cloonan joan k heath intestines / abnormalities liver / abnormalities pancreas / abnormalities point mutation / genetics rna splicing / genetics rna splicing / physiology* small nuclear / chemistry* rna-binding proteins / genetics* rna-binding proteins / metabolism spliceosomes / genetics spliceosomes / metabolism* zebrafish / growth & development zebrafish proteins / metabolism

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